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Hellboy is a comic book superhero created by writer-artist Mike Mignola. The character first appeared in San Diego Comic-Con Comics #2 (August 1993), and has since appeared in various eponymous miniseries, one-shots and intercompany crossovers. The character has been adapted into three live-action feature films – two starring Ron Perlman in 2004 and 2008 in the title role, and one in 2019 which starred David Harbour, as well as two straight-to-DVD animated films, again starring Perlman, and four video games – Asylum Seeker, The Science of Evil, as a playable character in Injustice 2, and Web of Wyrd.

Painkiller Jane is a fictional superheroine created by Jimmy Palmiotti and Joe Quesada for Event Comics in 1995. Originally a five-issue mini-series, the character went on to star in numerous crossover titles with the likes of the Punisher, Vampirella, and Hellboy.